* Shelley Long appeared in episode 4, “The Incident”, as Jay’s ex-wife.
* Edward Norton and Elizabeth Banks appeared on the November 18, 2009, episode, “Great Expectations”. Norton played Izzy LaFontaine, the fictional bassist of Spandau Ballet, whom Claire believed to be Phil’s favorite band; Banks portrayed Sal, Mitchell and Cameron’s old friend and reputed party girl, who they meet for a night on the town.
* Fred Willard made a brief cameo in a scene from “Undeck the Halls”, followed by an appearance in episode 21 (Travels with Scout) when he travels cross country without Phil’s mother and shows up with a dog, Scout. Willard received a 2010 Primetime Emmy Award nomination as Outstanding Guest Star in a Comedy Series on July 8, 2010.
* Comedian Mo Collins guest starred as Denise the nurse, who is the caretaker of Caroline, a little girl Manny defeated in a fencing match, in the episode “En Garde”.
* Chazz Palminteri guest starred as Shorty, a friend of Jay’s who may or may not be gay, in the same episode Kristen Schaal guest starred as Whitney, a woman Manny met online and believes he will take out on a date.
* Minnie Driver appeared as a friend and former co-worker of Claire’s in “Moon Landing”.
* David Brenner appeared as himself in “My Funky Valentine”.
* Judy Greer appeared as an ex-girlfriend of Phil’s in the episode “Truth Be Told”
* Justin Kirk appeared as an owner of a clothing line, which Mitchell starts to work at.
* Eric Lange appeared as a basketball coach.
* Kobe Bryant made a cameo appearance in the episode “Family Portrait”.
* Benjamin Bratt guest starred as Manny’s father Javier Delgado in “Up All Night”
* Nolan North guest starred in “En Garde” as a prospective client in one of Phil’s real estate showings.